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10.1186/s12935-017-0472-0 http://scihub22266oqcxt.onion/10.1186/s12935-017-0472-0 C5670729!5670729!29142505     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29142505.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Cell+Int 2017 ; 17 (ä): ä Nephropedia Template TP {{tp|p=29142505|t=2017. Targeting deubiquitinating enzymes in cancer stem cells |pdf=|usr=}}{{29142505}} gab.com Text Targeting deubiquitinating enzymes in cancer stem cells JO: Cancer Cell Int http://www.kidney.de/pget.php?&tw=1&pmid=29142505 #FOAvip Cancer stem cells (CSCs) are rare but accounted for tumor initiation, progression, metastasis, relapse and therapeutic resistance. Ubiquitination and deubiquitination of stemness-related proteins are essential for CSC maintenance and differentiation, even leading to execute various stem cell fate choices. Deubiquitinating enzymes (DUBs), specifically disassembling ubiquitin chains, are important to maintain the balance between ubiquitination and deubiquitination. In this review, we have focused on the DUBs regulation of stem cell fate determination. For example, we discuss deubiquitinase inhibition may lead stem cell transcription factors and CSCs-related protein degradation. Also, CSCs microenvironment is regulated by DUBs activity. Our review provides a new insight into DUBs activity by emphasizing their cellular role in regulating stem cell fate and illustrates the opportunities for the application of DUBs inhibitors in the CSC-targeted therapy. Twit Text FOAVip Targeting deubiquitinating enzymes in cancer stem cells ????Cancer Cell Int http://www.kidney.de/pget.php?&tw=1&pmid=29142505 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29142505 #FOAvip English Wikipedia <ref>{{Cite pmid|29142505}}</ref> Targeting deubiquitinating enzymes in cancer stem cells #MMPMID29142505 Lei H; Shan H; Wu Y Cancer Cell Int 2017[]; 17 (ä): ä PMID29142505show ga Cancer stem cells (CSCs) are rare but accounted for tumor initiation, progression, metastasis, relapse and therapeutic resistance. Ubiquitination and deubiquitination of stemness-related proteins are essential for CSC maintenance and differentiation, even leading to execute various stem cell fate choices. Deubiquitinating enzymes (DUBs), specifically disassembling ubiquitin chains, are important to maintain the balance between ubiquitination and deubiquitination. In this review, we have focused on the DUBs regulation of stem cell fate determination. For example, we discuss deubiquitinase inhibition may lead stem cell transcription factors and CSCs-related protein degradation. Also, CSCs microenvironment is regulated by DUBs activity. Our review provides a new insight into DUBs activity by emphasizing their cellular role in regulating stem cell fate and illustrates the opportunities for the application of DUBs inhibitors in the CSC-targeted therapy. äTargeting deubiquitinating enzymes in cancer stem cells (epmc).pdf DeepDyve Pubget Overpricing