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2015 ; 125
(5
): 1780-9
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Targeting cancer with kinase inhibitors
#MMPMID25932675
Gross S
; Rahal R
; Stransky N
; Lengauer C
; Hoeflich KP
J Clin Invest
2015[May]; 125
(5
): 1780-9
PMID25932675
show ga
Kinase inhibitors have played an increasingly prominent role in the treatment of
cancer and other diseases. Currently, more than 25 oncology drugs that target
kinases have been approved, and numerous additional therapeutics are in various
stages of clinical evaluation. In this Review, we provide an in-depth analysis of
activation mechanisms for kinases in cancer, highlight recent successes in drug
discovery, and demonstrate the clinical impact of selective kinase inhibitors. We
also describe the substantial progress that has been made in designing
next-generation inhibitors to circumvent on-target resistance mechanisms, as well
as ongoing strategies for combining kinase inhibitors in the clinic. Last, there
are numerous prospects for the discovery of novel kinase targets, and we explore
cancer immunotherapy as a new and promising research area for studying kinase
biology.
|Antineoplastic Agents/pharmacology/*therapeutic use
[MESH]
|Antineoplastic Combined Chemotherapy Protocols/pharmacology/therapeutic use
[MESH]
free
free
free
