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10.14348/molcells.2018.2297 http://scihub22266oqcxt.onion/10.14348/molcells.2018.2297 C6030247!6030247 !29754476     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29754476 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29754476 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Cells 2018 ; 41 (6 ): 506-514 Nephropedia Template TP {{tp|p=29754476 |t=2018. Targeting Super-Enhancers for Disease Treatment and Diagnosis |pdf=|usr=}}{{29754476 }} gab.com Text Targeting Super-Enhancers for Disease Treatment and Diagnosis JO: Mol Cells http://www.kidney.de/pget.php?&tw=1&pmid=29754476 #FOAvip The transcriptional regulation of genes determines the fate of animal cell differentiation and subsequent organ development. With the recent progress in genome-wide technologies, the genomic landscapes of enhancers have been broadly explored in mammalian genomes, which led to the discovery of novel specific subsets of enhancers, termed super-enhancers. Super-enhancers are large clusters of enhancers covering the long region of regulatory DNA and are densely occupied by transcription factors, active histone marks, and co-activators. Accumulating evidence points to the critical role that super-enhancers play in cell type-specific development and differentiation, as well as in the development of various diseases. Here, I provide a comprehensive description of the optimal approach for identifying functional units of super-enhancers and their unique chromatin features in normal development and in diseases, including cancers. I also review the recent updated knowledge on novel approaches of targeting super-enhancers for the treatment of specific diseases, such as small-molecule inhibitors and potential gene therapy. This review will provide perspectives on using super-enhancers as biomarkers to develop novel disease diagnostic tools and establish new directions in clinical therapeutic strategies. Twit Text FOAVip Targeting Super-Enhancers for Disease Treatment and Diagnosis ????Mol Cells http://www.kidney.de/pget.php?&tw=1&pmid=29754476 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29754476 #FOAvip English Wikipedia <ref>{{Cite pmid|29754476 }}</ref> Targeting Super-Enhancers for Disease Treatment and Diagnosis #MMPMID29754476 Shin HY Mol Cells 2018[Jun]; 41 (6 ): 506-514 PMID29754476 show ga The transcriptional regulation of genes determines the fate of animal cell differentiation and subsequent organ development. With the recent progress in genome-wide technologies, the genomic landscapes of enhancers have been broadly explored in mammalian genomes, which led to the discovery of novel specific subsets of enhancers, termed super-enhancers. Super-enhancers are large clusters of enhancers covering the long region of regulatory DNA and are densely occupied by transcription factors, active histone marks, and co-activators. Accumulating evidence points to the critical role that super-enhancers play in cell type-specific development and differentiation, as well as in the development of various diseases. Here, I provide a comprehensive description of the optimal approach for identifying functional units of super-enhancers and their unique chromatin features in normal development and in diseases, including cancers. I also review the recent updated knowledge on novel approaches of targeting super-enhancers for the treatment of specific diseases, such as small-molecule inhibitors and potential gene therapy. This review will provide perspectives on using super-enhancers as biomarkers to develop novel disease diagnostic tools and establish new directions in clinical therapeutic strategies. |Animals [MESH] |Cell Differentiation [MESH] |Disease/*genetics [MESH] |Enhancer Elements, Genetic/*genetics [MESH]Targeting Super-Enhancers for Disease Treatment and Diagnosis (epmc).pdf DeepDyve Pubget Overpricing