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10.1002/cmdc.201600012 http://scihub22266oqcxt.onion/10.1002/cmdc.201600012 C4848768!4848768 !26997519     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26997519 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       ChemMedChem 2016 ; 11 (8 ): 773-86 Nephropedia Template TP {{tp|p=26997519 |t=2016. Targeting Protein-Protein Interactions in the HIF System |pdf=|usr=}}{{26997519 }} gab.com Text Targeting Protein-Protein Interactions in the HIF System JO: ChemMedChem http://www.kidney.de/pget.php?&tw=1&pmid=26997519 #FOAvip Animals respond to chronic hypoxia by increasing the levels of a transcription factor known as the hypoxia-inducible factor (HIF). HIF upregulates multiple genes, the products of which work to ameliorate the effects of limited oxygen at cellular and systemic levels. Hypoxia sensing by the HIF system involves hydroxylase-catalysed post-translational modifications of the HIF ?-subunits, which 1)?signal for degradation of HIF-? and 2)?limit binding of HIF to transcriptional coactivator proteins. Because the hypoxic response is relevant to multiple disease states, therapeutic manipulation of the HIF-mediated response has considerable medicinal potential. In addition to modulation of catalysis by the HIF hydroxylases, the HIF system manifests other possibilities for therapeutic intervention involving protein-protein and protein-nucleic acid interactions. Recent advances in our understanding of the structural biology and biochemistry of the HIF system are facilitating medicinal chemistry efforts. Herein we give an overview of the HIF system, focusing on structural knowledge of protein-protein interactions and how this might be used to modulate the hypoxic response for therapeutic benefit. Twit Text FOAVip Targeting Protein-Protein Interactions in the HIF System ????ChemMedChem http://www.kidney.de/pget.php?&tw=1&pmid=26997519 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26997519 #FOAvip English Wikipedia <ref>{{Cite pmid|26997519 }}</ref> Targeting Protein-Protein Interactions in the HIF System #MMPMID26997519 Wilkins SE ; Abboud MI ; Hancock RL ; Schofield CJ ChemMedChem 2016[Apr]; 11 (8 ): 773-86 PMID26997519 show ga Animals respond to chronic hypoxia by increasing the levels of a transcription factor known as the hypoxia-inducible factor (HIF). HIF upregulates multiple genes, the products of which work to ameliorate the effects of limited oxygen at cellular and systemic levels. Hypoxia sensing by the HIF system involves hydroxylase-catalysed post-translational modifications of the HIF ?-subunits, which 1)?signal for degradation of HIF-? and 2)?limit binding of HIF to transcriptional coactivator proteins. Because the hypoxic response is relevant to multiple disease states, therapeutic manipulation of the HIF-mediated response has considerable medicinal potential. In addition to modulation of catalysis by the HIF hydroxylases, the HIF system manifests other possibilities for therapeutic intervention involving protein-protein and protein-nucleic acid interactions. Recent advances in our understanding of the structural biology and biochemistry of the HIF system are facilitating medicinal chemistry efforts. Herein we give an overview of the HIF system, focusing on structural knowledge of protein-protein interactions and how this might be used to modulate the hypoxic response for therapeutic benefit. |Animals [MESH] |Humans [MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/*chemistry/*metabolism [MESH] |Nucleic Acids/chemistry/metabolism [MESH] |Protein Binding/drug effects [MESH]Targeting Protein-Protein Interactions in the HIF System (epmc).pdf DeepDyve Pubget Overpricing