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10.18632/oncotarget.6714 http://scihub22266oqcxt.onion/10.18632/oncotarget.6714 C4884942!4884942 !26713603     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26713603 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26713603 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (7 ): 7610-28 Nephropedia Template TP {{tp|p=26713603 |t=2016. Targeting Notch to overcome radiation resistance |pdf=|usr=}}{{26713603 }} gab.com Text Targeting Notch to overcome radiation resistance JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26713603 #FOAvip Radiotherapy represents an important therapeutic strategy in the treatment of cancer cells. However, it often fails to eliminate all tumor cells because of the intrinsic or acquired treatment resistance, which is the most common cause of tumor recurrence. Emerging evidences suggest that the Notch signaling pathway is an important pathway mediating radiation resistance in tumor cells. Successful targeting of Notch signaling requires a thorough understanding of Notch regulation and the context-dependent interactions between Notch and other therapeutically relevant pathways. Understanding these interactions will increase our ability to design rational combination regimens that are more likely to be safe and effective. Here we summarize the role of Notch in mediating resistance to radiotherapy, the different strategies to block Notch in cancer cells and how treatment scheduling can improve tumor response. Finally, we discuss a need for reliable Notch related biomarkers in specific tumors to measure pathway activity and to allow identification of a subset of patients who are likely to benefit from Notch targeted therapies. Twit Text FOAVip Targeting Notch to overcome radiation resistance ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26713603 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26713603 #FOAvip English Wikipedia <ref>{{Cite pmid|26713603 }}</ref> Targeting Notch to overcome radiation resistance #MMPMID26713603 Yahyanejad S ; Theys J ; Vooijs M Oncotarget 2016[Feb]; 7 (7 ): 7610-28 PMID26713603 show ga Radiotherapy represents an important therapeutic strategy in the treatment of cancer cells. However, it often fails to eliminate all tumor cells because of the intrinsic or acquired treatment resistance, which is the most common cause of tumor recurrence. Emerging evidences suggest that the Notch signaling pathway is an important pathway mediating radiation resistance in tumor cells. Successful targeting of Notch signaling requires a thorough understanding of Notch regulation and the context-dependent interactions between Notch and other therapeutically relevant pathways. Understanding these interactions will increase our ability to design rational combination regimens that are more likely to be safe and effective. Here we summarize the role of Notch in mediating resistance to radiotherapy, the different strategies to block Notch in cancer cells and how treatment scheduling can improve tumor response. Finally, we discuss a need for reliable Notch related biomarkers in specific tumors to measure pathway activity and to allow identification of a subset of patients who are likely to benefit from Notch targeted therapies. |Animals [MESH] |Humans [MESH] |Neoplasms/*prevention & control [MESH] |Radiation Tolerance/*drug effects [MESH] |Radiation-Sensitizing Agents/*therapeutic use [MESH]Targeting Notch to overcome radiation resistance (epmc).pdf DeepDyve Pubget Overpricing