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10.3389/fimmu.2015.00547

http://scihub22266oqcxt.onion/10.3389/fimmu.2015.00547
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C4617050!4617050 !26557123
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suck abstract from ncbi


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pmid26557123
      Front+Immunol 2015 ; 6 (ä): 547
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  • Targeting CD8 T-Cell Metabolism in Transplantation #MMPMID26557123
  • Yap M ; Brouard S ; Pecqueur C ; Degauque N
  • Front Immunol 2015[]; 6 (ä): 547 PMID26557123 show ga
  • Infiltration of effector CD8 T cells plays a major role in allograft rejection, and increases in memory and terminally differentiated effector memory CD8 T cells are associated with long-term allograft dysfunction. Alternatively, CD8 regulatory T cells suppress the inflammatory responses of effector lymphocytes and induce allograft tolerance in animal models. Recently, there has been a renewed interest in the field of immunometabolics and its important role in CD8 function and differentiation. The purpose of this review is to highlight the key metabolic pathways involved in CD8 T cells and to discuss how manipulating these metabolic pathways could lead to new immunosuppressive strategies for the transplantation field.
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