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10.2217/imt.15.77 http://scihub22266oqcxt.onion/10.2217/imt.15.77 C4976846!4976846 !26370838     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26370838 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26370838 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Immunotherapy 2015 ; 7 (11 ): 1187-99 Nephropedia Template TP {{tp|p=26370838 |t=2015. Targeting B-cell maturation antigen in multiple myeloma |pdf=|usr=}}{{26370838 }} gab.com Text Targeting B-cell maturation antigen in multiple myeloma JO: Immunotherapy http://www.kidney.de/pget.php?&tw=1&pmid=26370838 #FOAvip Novel effective immunotherapies are needed for patients with multiple myeloma (MM), since disease recurrence remains a major obstacle. B-cell maturation antigen (BCMA), a cell surface protein universally expressed on malignant plasma cells , has emerged as a very selective antigen to be targeted in novel treatments for MM. We here first review BCMA-related biology, and then highlight the recent clinical development of a novel afucosylated anti-BCMA monoclonal antibody conjugated with monomethyl auristatin F via noncleavable linker (GSK2857916). Chimeric antigen receptor-expressing T cells targeting BCMA may also induce specific and durable anti-MM responses by patients' own effector cells. Clinical trials testing these two approaches (NCT02064387, NCT02215967) are currently ongoing in relapsed and refractory MM patients. Twit Text FOAVip Targeting B-cell maturation antigen in multiple myeloma ????Immunotherapy http://www.kidney.de/pget.php?&tw=1&pmid=26370838 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26370838 #FOAvip English Wikipedia <ref>{{Cite pmid|26370838 }}</ref> Targeting B-cell maturation antigen in multiple myeloma #MMPMID26370838 Tai YT ; Anderson KC Immunotherapy 2015[]; 7 (11 ): 1187-99 PMID26370838 show ga Novel effective immunotherapies are needed for patients with multiple myeloma (MM), since disease recurrence remains a major obstacle. B-cell maturation antigen (BCMA), a cell surface protein universally expressed on malignant plasma cells , has emerged as a very selective antigen to be targeted in novel treatments for MM. We here first review BCMA-related biology, and then highlight the recent clinical development of a novel afucosylated anti-BCMA monoclonal antibody conjugated with monomethyl auristatin F via noncleavable linker (GSK2857916). Chimeric antigen receptor-expressing T cells targeting BCMA may also induce specific and durable anti-MM responses by patients' own effector cells. Clinical trials testing these two approaches (NCT02064387, NCT02215967) are currently ongoing in relapsed and refractory MM patients. |*Immunotherapy [MESH] |Animals [MESH] |Antibodies, Monoclonal/chemistry/*therapeutic use [MESH] |Antigens, Neoplasm/immunology/*metabolism [MESH] |B-Cell Maturation Antigen/immunology/*metabolism [MESH] |Clinical Trials as Topic [MESH] |Humans [MESH] |Molecular Targeted Therapy [MESH] |Multiple Myeloma/immunology/*therapy [MESH] |Oligopeptides/chemistry [MESH] |Protein Engineering [MESH] |Receptors, Antigen, T-Cell/genetics [MESH] |Recombinant Fusion Proteins/genetics [MESH]Targeting B-cell maturation antigen in multiple myeloma (epmc).pdf DeepDyve Pubget Overpricing