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10.1002/anie.201506818

http://scihub22266oqcxt.onion/10.1002/anie.201506818
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C5071768!5071768 !27000559
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suck abstract from ncbi


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pmid27000559
      Angew+Chem+Int+Ed+Engl 2016 ; 55 (23 ): 6600-26
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  • Targeting Antibiotic Resistance #MMPMID27000559
  • Chellat MF ; Ragu? L ; Riedl R
  • Angew Chem Int Ed Engl 2016[Jun]; 55 (23 ): 6600-26 PMID27000559 show ga
  • Finding strategies against the development of antibiotic resistance is a major global challenge for the life sciences community and for public health. The past decades have seen a dramatic worldwide increase in human-pathogenic bacteria that are resistant to one or multiple antibiotics. More and more infections caused by resistant microorganisms fail to respond to conventional treatment, and in some cases, even last-resort antibiotics have lost their power. In addition, industry pipelines for the development of novel antibiotics have run dry over the past decades. A recent world health day by the World Health Organization titled "Combat drug resistance: no action today means no cure tomorrow" triggered an increase in research activity, and several promising strategies have been developed to restore treatment options against infections by resistant bacterial pathogens.
  • |Anti-Bacterial Agents/chemistry/*pharmacology [MESH]
  • |Bacteria/metabolism [MESH]
  • |Bacterial Proteins/antagonists & inhibitors/biosynthesis [MESH]
  • |Drug Design [MESH]
  • |Drug Resistance, Multiple, Bacterial/*drug effects [MESH]
  • |Macrolides/chemistry/pharmacology [MESH]
  • |Molecular Dynamics Simulation [MESH]
  • |Organophosphates/chemistry/pharmacology [MESH]
  • |Oxazoles/chemistry/pharmacology [MESH]
  • |Oxazolidinones/chemistry/pharmacology [MESH]


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