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2016 ; 55
(23
): 6600-26
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Targeting Antibiotic Resistance
#MMPMID27000559
Chellat MF
; Ragu? L
; Riedl R
Angew Chem Int Ed Engl
2016[Jun]; 55
(23
): 6600-26
PMID27000559
show ga
Finding strategies against the development of antibiotic resistance is a major
global challenge for the life sciences community and for public health. The past
decades have seen a dramatic worldwide increase in human-pathogenic bacteria that
are resistant to one or multiple antibiotics. More and more infections caused by
resistant microorganisms fail to respond to conventional treatment, and in some
cases, even last-resort antibiotics have lost their power. In addition, industry
pipelines for the development of novel antibiotics have run dry over the past
decades. A recent world health day by the World Health Organization titled
"Combat drug resistance: no action today means no cure tomorrow" triggered an
increase in research activity, and several promising strategies have been
developed to restore treatment options against infections by resistant bacterial
pathogens.