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10.1016/j.trecan.2017.05.004

http://scihub22266oqcxt.onion/10.1016/j.trecan.2017.05.004
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C5646417!5646417 !28718401
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suck abstract from ncbi

pmid28718401
      Trends+Cancer 2017 ; 3 (7 ): 471-474
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  • Targeting ATF5 in Cancer #MMPMID28718401
  • Angelastro JM
  • Trends Cancer 2017[Jul]; 3 (7 ): 471-474 PMID28718401 show ga
  • The expression of activating transcription factor 5 (ATF5) correlates negatively with patient survival in different types of cancer. ATF5 is important for the survival and proliferation of cancer cells, and can be targeted to selectively trigger cancer cell apoptosis while sparing normal cells. Cell-penetrating peptides combined with a dominant negative ATF5 cargo have recently shown efficacy against brain, breast, melanoma, and prostate cancers.
  • |Activating Transcription Factors/*antagonists & inhibitors/genetics/metabolism [MESH]
  • |Animals [MESH]
  • |Antineoplastic Agents/*pharmacology/therapeutic use [MESH]
  • |Apoptosis/*drug effects [MESH]
  • |Cell Line, Tumor [MESH]
  • |Cell Proliferation/drug effects [MESH]
  • |Cell Survival/drug effects [MESH]
  • |Cell-Penetrating Peptides/*pharmacology/therapeutic use [MESH]
  • |Female [MESH]
  • |Gene Expression Regulation, Neoplastic/*drug effects [MESH]
  • |Humans [MESH]
  • |Male [MESH]
  • |Mice [MESH]
  • |Neoplasms/*drug therapy/genetics [MESH]
  • |Rats [MESH]
  • |Recombinant Proteins/pharmacology/therapeutic use [MESH]


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