Trends Cancer
2017[Jul]; 3
(7
): 471-474
PMID28718401
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The expression of activating transcription factor 5 (ATF5) correlates negatively
with patient survival in different types of cancer. ATF5 is important for the
survival and proliferation of cancer cells, and can be targeted to selectively
trigger cancer cell apoptosis while sparing normal cells. Cell-penetrating
peptides combined with a dominant negative ATF5 cargo have recently shown
efficacy against brain, breast, melanoma, and prostate cancers.