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2018 ; 15
(2
): 402-414
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Targeted Acid-Sensing Ion Channel Therapies for Migraine
#MMPMID29549622
Karsan N
; Gonzales EB
; Dussor G
Neurotherapeutics
2018[Apr]; 15
(2
): 402-414
PMID29549622
show ga
Acid-sensing ion channels (ASICs) are a family of ion channels, consisting of
four members; ASIC1 to 4. These channels are sensitive to changes in pH and are
expressed throughout the central and peripheral nervous systems-including brain,
spinal cord, and sensory ganglia. They have been implicated in a number of
neurological conditions such as stroke and cerebral ischemia, traumatic brain
injury, and epilepsy, and more recently in migraine. Their expression within
areas of interest in the brain in migraine, such as the hypothalamus and PAG,
their demonstrated involvement in preclinical models of meningeal afferent
signaling, and their role in cortical spreading depression (the
electrophysiological correlate of migraine aura), has enhanced research interest
into these channels as potential therapeutic targets in migraine. Migraine is a
disorder with a paucity of both acute and preventive therapies available, in
which at best 50% of patients respond to available medications, and these
medications often have intolerable side effects. There is therefore a great need
for therapeutic development for this disabling condition. This review will
summarize the understanding of the structure and CNS expression of ASICs, the
mechanisms for their potential role in nociception, recent work in migraine, and
areas for future research and drug development.
|Acid Sensing Ion Channel Blockers/therapeutic use
[MESH]
|Acid Sensing Ion Channels/*metabolism/pharmacology
[MESH]
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