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10.1038/s41594-018-0054-4 http://scihub22266oqcxt.onion/10.1038/s41594-018-0054-4 C6052442!6052442 !29662218     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29662218 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29662218 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Struct+Mol+Biol 2018 ; 25 (5 ): 357-364 Nephropedia Template TP {{tp|p=29662218 |t=2018. Tapping the RNA world for therapeutics |pdf=|usr=}}{{29662218 }} gab.com Text Tapping the RNA world for therapeutics JO: Nat Struct Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=29662218 #FOAvip A recent revolution in RNA biology has led to the identification of new RNA classes with unanticipated functions, new types of RNA modifications, an unexpected multiplicity of alternative transcripts and widespread transcription of extragenic regions. This development in basic RNA biology has spawned a corresponding revolution in RNA-based strategies to generate new types of therapeutics. Here, I review RNA-based drug design and discuss barriers to broader applications and possible ways to overcome them. Because they target nucleic acids rather than proteins, RNA-based drugs promise to greatly extend the domain of 'druggable' targets beyond what can be achieved with small molecules and biologics. Twit Text FOAVip Tapping the RNA world for therapeutics ????Nat Struct Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=29662218 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29662218 #FOAvip English Wikipedia <ref>{{Cite pmid|29662218 }}</ref> Tapping the RNA world for therapeutics #MMPMID29662218 Lieberman J Nat Struct Mol Biol 2018[May]; 25 (5 ): 357-364 PMID29662218 show ga A recent revolution in RNA biology has led to the identification of new RNA classes with unanticipated functions, new types of RNA modifications, an unexpected multiplicity of alternative transcripts and widespread transcription of extragenic regions. This development in basic RNA biology has spawned a corresponding revolution in RNA-based strategies to generate new types of therapeutics. Here, I review RNA-based drug design and discuss barriers to broader applications and possible ways to overcome them. Because they target nucleic acids rather than proteins, RNA-based drugs promise to greatly extend the domain of 'druggable' targets beyond what can be achieved with small molecules and biologics. |Alternative Splicing/genetics [MESH] |CRISPR-Cas Systems/genetics [MESH] |Drug Design [MESH] |Humans [MESH] |Nucleic Acid Conformation [MESH] |RNA, Long Noncoding/*genetics [MESH] |RNA, Small Interfering/*genetics [MESH]Tapping the RNA world for therapeutics (epmc).pdf DeepDyve Pubget Overpricing