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10.1158/0008-5472.CAN-11-3863 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-11-3863 22871386!ä!22871386 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\22871386.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Res 2012 ; 72 (16): 4250-61 Nephropedia Template TP {{tp|p=22871386|t=2012. TRPM7 is required for breast tumor cell metastasis |pdf=|usr=}}{{22871386}} gab.com Text TRPM7 is required for breast tumor cell metastasis JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=22871386 #FOAvip TRPM7 encodes a Ca2+-permeable nonselective cation channel with kinase activity. TRPM7 has been implicated in control of cell adhesion and migration, but whether TRPM7 activity contributes to cancer progression has not been established. Here we report that high levels of TRPM7 expression independently predict poor outcome in breast cancer patients and that it is functionally required for metastasis formation in a mouse xenograft model of human breast cancer. Mechanistic investigation revealed that TRPM7 regulated myosin II-based cellular tension, thereby modifying focal adhesion number, cell-cell adhesion and polarized cell movement. Our findings therefore suggest that TRPM7 is part of a mechanosensory complex adopted by cancer cells to drive metastasis formation. Twit Text FOAVip TRPM7 is required for breast tumor cell metastasis ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=22871386 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22871386 #FOAvip English Wikipedia <ref>{{Cite pmid|22871386}}</ref> TRPM7 is required for breast tumor cell metastasis #MMPMID22871386 Middelbeek J; Kuipers AJ; Henneman L; Visser D; Eidhof I; van Horssen R; Wieringa B; Canisius SV; Zwart W; Wessels LF; Sweep FC; Bult P; Span PN; van Leeuwen FN; Jalink K Cancer Res 2012[Aug]; 72 (16): 4250-61 PMID22871386show ga TRPM7 encodes a Ca2+-permeable nonselective cation channel with kinase activity. TRPM7 has been implicated in control of cell adhesion and migration, but whether TRPM7 activity contributes to cancer progression has not been established. Here we report that high levels of TRPM7 expression independently predict poor outcome in breast cancer patients and that it is functionally required for metastasis formation in a mouse xenograft model of human breast cancer. Mechanistic investigation revealed that TRPM7 regulated myosin II-based cellular tension, thereby modifying focal adhesion number, cell-cell adhesion and polarized cell movement. Our findings therefore suggest that TRPM7 is part of a mechanosensory complex adopted by cancer cells to drive metastasis formation. |Animals[MESH] |Breast Neoplasms/genetics/*metabolism/*pathology[MESH] |Cell Adhesion/physiology[MESH] |Cell Line, Tumor[MESH] |Cell Movement/physiology[MESH] |Cytoskeleton/drug effects/pathology[MESH] |Disease Progression[MESH] |Female[MESH] |Gene Knockdown Techniques[MESH] |Humans[MESH] |Mice[MESH] |Mice, Transgenic[MESH] |Neoplasm Metastasis[MESH] |Neoplasm Staging[MESH] |Protein Serine-Threonine Kinases[MESH] |RNA, Messenger/biosynthesis/genetics[MESH] |Receptors, Estrogen/biosynthesis/metabolism[MESH]TRPM7 is required for breast tumor cell metastasis (epmc).pdf DeepDyve Pubget Overpricing