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2015 ; 2
(2
): e970951
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TRIM32 is a novel negative regulator of p53
#MMPMID27308422
Liu J
; Zhu Y
; Hu W
; Feng Z
Mol Cell Oncol
2015[Apr]; 2
(2
): e970951
PMID27308422
show ga
To ensure proper function, the tumor suppressor p53 is tightly regulated through
different post-translational modifications, particularly ubiquitination.
Recently, TRIM32 was identified as a p53-regulated gene and an E3 ubiquitin
ligase of p53. Thus, TRIM32 and p53 form a novel auto-regulatory negative
feedback loop for p53 regulation in cells.