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10.4103/0253-7613.165190

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suck abstract from ncbi


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pmid26600634
      Indian+J+Pharmacol 2015 ; 47 (5 ): 479-83
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  • TNFerade, an innovative cancer immunotherapeutic #MMPMID26600634
  • Kali A
  • Indian J Pharmacol 2015[Sep]; 47 (5 ): 479-83 PMID26600634 show ga
  • Tumor necrosis factor-? (TNF-?) is a chemokine with effective tumoricidal properties. However, severe systemic toxicity limits its use of as anticancer agent. TNFerade is a novel replication deficient adenovector based gene therapy, which enables the radiation inducible translation of human TNF-? gene specifically in cancer cells. When injected intratumorally, it has least systemic distribution. Consequently, it lacks TNF-? related systemic toxicity. Evidence suggests that it has superior tumoricidal activity and tolerability with minimum adverse effects. It has demonstrated its beneficial role in the treatment of a variety of cancers in terms of improving the disease free and overall survival, delaying tumor progression, and inducing tumor regression when used with concurrent radiotherapy or chemotherapy.
  • |Animals [MESH]
  • |DNA/administration & dosage [MESH]
  • |Disease Progression [MESH]
  • |Disease-Free Survival [MESH]
  • |Genetic Therapy/*methods [MESH]
  • |Humans [MESH]
  • |Immunotherapy/methods [MESH]
  • |Neoplasms/genetics/immunology/*therapy [MESH]
  • |Survival Rate [MESH]


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