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2015 ; 47
(5
): 479-83
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TNFerade, an innovative cancer immunotherapeutic
#MMPMID26600634
Kali A
Indian J Pharmacol
2015[Sep]; 47
(5
): 479-83
PMID26600634
show ga
Tumor necrosis factor-? (TNF-?) is a chemokine with effective tumoricidal
properties. However, severe systemic toxicity limits its use of as anticancer
agent. TNFerade is a novel replication deficient adenovector based gene therapy,
which enables the radiation inducible translation of human TNF-? gene
specifically in cancer cells. When injected intratumorally, it has least systemic
distribution. Consequently, it lacks TNF-? related systemic toxicity. Evidence
suggests that it has superior tumoricidal activity and tolerability with minimum
adverse effects. It has demonstrated its beneficial role in the treatment of a
variety of cancers in terms of improving the disease free and overall survival,
delaying tumor progression, and inducing tumor regression when used with
concurrent radiotherapy or chemotherapy.