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2011 ; 1
(1
): 201-219
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THz Medical Imaging: in vivo Hydration Sensing
#MMPMID26085958
Taylor ZD
; Singh RS
; Bennett DB
; Tewari P
; Kealey CP
; Bajwa N
; Culjat MO
; Stojadinovic A
; Lee H
; Hubschman JP
; Brown ER
; Grundfest WS
IEEE Trans Terahertz Sci Technol
2011[Sep]; 1
(1
): 201-219
PMID26085958
show ga
The application of THz to medical imaging is experiencing a surge in both
interest and federal funding. A brief overview of the field is provided along
with promising and emerging applications and ongoing research. THz imaging
phenomenology is discussed and tradeoffs are identified. A THz medical imaging
system, operating at ~525 GHz center frequency with ~125 GHz of response
normalized bandwidth is introduced and details regarding principles of operation
are provided. Two promising medical applications of THz imaging are presented:
skin burns and cornea. For burns, images of second degree, partial thickness
burns were obtained in rat models in vivo over an 8 hour period. These images
clearly show the formation and progression of edema in and around the burn wound
area. For cornea, experimental data measuring the hydration of ex vivo porcine
cornea under drying is presented demonstrating utility in ophthalmologic
applications.