Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26513707
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
THE GLYCOCALYX AND TRAUMA: A REVIEW
#MMPMID26513707
Chignalia AZ
; Yetimakman F
; Christiaans SC
; Unal S
; Bayrakci B
; Wagener BM
; Russell RT
; Kerby JD
; Pittet JF
; Dull RO
Shock
2016[Apr]; 45
(4
): 338-48
PMID26513707
show ga
In the United States trauma is the leading cause of mortality among those under
the age of 45, claiming approximately 192,000 lives each year. Significant
personal disability, lost productivity, and long-term healthcare needs are common
and contribute 580 billion dollars in economic impact each year. Improving
resuscitation strategies and the early acute care of trauma patients has the
potential to reduce the pathological sequelae of combined exuberant inflammation
and immune suppression that can co-exist, or occur temporally, and adversely
affect outcomes. The endothelial and epithelial glycocalyx has emerged as an
important participant in both inflammation and immunomodulation. Constituents of
the glycocalyx have been used as biomarkers of injury severity and have the
potential to be target(s) for therapeutic interventions aimed at immune
modulation. In this review, we provide a contemporary understanding of the
physiologic structure and function of the glycocalyx and its role in traumatic
injury with a particular emphasis on lung injury.
free
free
free
