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10.1895/wormbook.1.22.1 http://scihub22266oqcxt.onion/10.1895/wormbook.1.22.1 C4781025!4781025 !18050404     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\18050404 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       WormBook 2005 ; ä (ä): 1-12 Nephropedia Template TP {{tp|p=18050404 |t=2005. TGF-beta signaling |pdf=|usr=}}{{18050404 }} gab.com Text TGF-beta signaling JO: WormBook http://www.kidney.de/pget.php?&tw=1&pmid=18050404 #FOAvip TGF-beta superfamily ligands play fundamental roles in the development and physiology of diverse animal species. Genetic and genomic analyses in the model organism Caenorhabditis elegans have contributed to the understanding of TGF-beta-related signal transduction mechanisms. In this chapter, I describe the currently characterized TGF-beta-related signals and signal transduction cassettes in C. elegans. Homology searches of the genome identify five TGF-beta-related genes, for which functions have been identified for three. Two of the TGF-beta-related genes, daf-7 and dbl-1, function through conventional signaling pathways. These signaling pathways are comprised of ser/thr kinase receptors, Smads, and transcription co-factors. A third TGF-beta-related gene, unc-129, functions in axonal guidance using novel signaling mechanisms. Thus, TGF-beta-related signaling in C. elegans proceeds via both conserved and novel paradigms that can inform studies in other animal systems. Twit Text FOAVip TGF-beta signaling ????WormBook http://www.kidney.de/pget.php?&tw=1&pmid=18050404 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18050404 #FOAvip English Wikipedia <ref>{{Cite pmid|18050404 }}</ref> TGF-beta signaling #MMPMID18050404 Savage-Dunn C WormBook 2005[Sep]; ä (ä): 1-12 PMID18050404 show ga TGF-beta superfamily ligands play fundamental roles in the development and physiology of diverse animal species. Genetic and genomic analyses in the model organism Caenorhabditis elegans have contributed to the understanding of TGF-beta-related signal transduction mechanisms. In this chapter, I describe the currently characterized TGF-beta-related signals and signal transduction cassettes in C. elegans. Homology searches of the genome identify five TGF-beta-related genes, for which functions have been identified for three. Two of the TGF-beta-related genes, daf-7 and dbl-1, function through conventional signaling pathways. These signaling pathways are comprised of ser/thr kinase receptors, Smads, and transcription co-factors. A third TGF-beta-related gene, unc-129, functions in axonal guidance using novel signaling mechanisms. Thus, TGF-beta-related signaling in C. elegans proceeds via both conserved and novel paradigms that can inform studies in other animal systems. |*Signal Transduction [MESH] |Animals [MESH] |Caenorhabditis elegans Proteins/genetics/metabolism [MESH] |Caenorhabditis elegans/genetics/*metabolism [MESH] |Humans [MESH] |Larva/metabolism [MESH]TGF-beta signaling (epmc).pdf DeepDyve Pubget Overpricing