Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27039259
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Cancer+Lett
2016 ; 379
(2
): 166-72
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
TGF-? signaling in liver and gastrointestinal cancers
#MMPMID27039259
Katz LH
; Likhter M
; Jogunoori W
; Belkin M
; Ohshiro K
; Mishra L
Cancer Lett
2016[Sep]; 379
(2
): 166-72
PMID27039259
show ga
Transforming Growth Factor-? (TGF-?) plays crucial and complex roles in liver and
gastrointestinal cancers. These include a multitude of distinct functions, such
as maintaining stem cell homeostasis, promoting fibrosis, immune modulating, as a
tumor suppressor and paradoxically, as a tumor progressor. However, key
mechanisms for the switches responsible for these distinct actions are poorly
understood, and remain a challenge. The Cancer Genome Atlas (TCGA) analyses and
genetically engineered mouse models now provide an integrated approach to dissect
these multifaceted and context-dependent driving roles of the TGF-? pathway. In
this review, we will discuss the molecular mechanisms of TGF-? signaling,
focusing on colorectal, gastric, pancreatic, and liver cancers. Novel drugs
targeting the TGF-? pathway have been developed over the last decade, and some
have been proven effective in clinical trials. A better understanding of the
TGF-? pathway may improve our ability to target it, thus providing more tools to
the armamentarium against these deadly cancers.
free
free
free
