Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.3109/08977194.2011.595714 http://scihub22266oqcxt.onion/10.3109/08977194.2011.595714 C4408550!4408550 !21740331     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=21740331 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\21740331 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Growth+Factors 2011 ; 29 (5 ): 196-202 Nephropedia Template TP {{tp|p=21740331 |t=2011. TGF-? signaling in fibrosis |pdf=|usr=}}{{21740331 }} gab.com Text TGF- signaling in fibrosis JO: Growth Factors http://www.kidney.de/pget.php?&tw=1&pmid=21740331 #FOAvip Transforming growth factor ? (TGF-?) is a central mediator of fibrogenesis. TGF-? is upregulated and activated in fibrotic diseases and modulates fibroblast phenotype and function, inducing myofibroblast transdifferentiation while promoting matrix preservation. Studies in a wide range of experimental models have demonstrated the involvement of the canonical activin receptor-like kinase 5/Smad3 pathway in fibrosis. Smad-independent pathways may regulate Smad activation and, under certain conditions, may directly transduce fibrogenic signals. The profibrotic actions of TGF-? are mediated, at least in part, through induction of its downstream effector, connective tissue growth factor. In light of its essential role in the pathogenesis of fibrosis, TGF-? has emerged as an attractive therapeutic target. However, the pleiotropic and multifunctional effects of TGF-? and its role in tissue homeostasis, immunity and cell proliferation raise concerns regarding potential side effects that may be caused by TGF-? blockade. This minireview summarizes the role of TGF-? signaling pathways in the fibrotic response. Twit Text FOAVip TGF- signaling in fibrosis ????Growth Factors http://www.kidney.de/pget.php?&tw=1&pmid=21740331 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21740331 #FOAvip English Wikipedia <ref>{{Cite pmid|21740331 }}</ref> TGF-? signaling in fibrosis #MMPMID21740331 Biernacka A ; Dobaczewski M ; Frangogiannis NG Growth Factors 2011[Oct]; 29 (5 ): 196-202 PMID21740331 show ga Transforming growth factor ? (TGF-?) is a central mediator of fibrogenesis. TGF-? is upregulated and activated in fibrotic diseases and modulates fibroblast phenotype and function, inducing myofibroblast transdifferentiation while promoting matrix preservation. Studies in a wide range of experimental models have demonstrated the involvement of the canonical activin receptor-like kinase 5/Smad3 pathway in fibrosis. Smad-independent pathways may regulate Smad activation and, under certain conditions, may directly transduce fibrogenic signals. The profibrotic actions of TGF-? are mediated, at least in part, through induction of its downstream effector, connective tissue growth factor. In light of its essential role in the pathogenesis of fibrosis, TGF-? has emerged as an attractive therapeutic target. However, the pleiotropic and multifunctional effects of TGF-? and its role in tissue homeostasis, immunity and cell proliferation raise concerns regarding potential side effects that may be caused by TGF-? blockade. This minireview summarizes the role of TGF-? signaling pathways in the fibrotic response. |Animals [MESH] |Cell Differentiation [MESH] |Cell Proliferation [MESH] |Connective Tissue Growth Factor/metabolism [MESH] |Extracellular Matrix/*pathology [MESH] |Fibroblasts/metabolism [MESH] |Fibrosis/*metabolism/pathology/physiopathology [MESH] |Humans [MESH] |Mice [MESH] |Mitogen-Activated Protein Kinases/metabolism [MESH] |Signal Transduction [MESH] |Smad Proteins/metabolism [MESH]TGF-? signaling in fibrosis (epmc).pdf DeepDyve Pubget Overpricing