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2016 ; 129
(13
): 2475-81
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TFEB at a glance
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Napolitano G
; Ballabio A
J Cell Sci
2016[Jul]; 129
(13
): 2475-81
PMID27252382
show ga
The transcription factor EB (TFEB) plays a pivotal role in the regulation of
basic cellular processes, such as lysosomal biogenesis and autophagy. The
subcellular localization and activity of TFEB are regulated by mechanistic target
of rapamycin (mTOR)-mediated phosphorylation, which occurs at the lysosomal
surface. Phosphorylated TFEB is retained in the cytoplasm, whereas
dephosphorylated TFEB translocates to the nucleus to induce the transcription of
target genes. Thus, a lysosome-to-nucleus signaling pathway regulates cellular
energy metabolism through TFEB. Recently, in vivo studies have revealed that TFEB
is also involved in physiological processes, such as lipid catabolism. TFEB has
attracted a lot of attention owing to its ability to induce the intracellular
clearance of pathogenic factors in a variety of murine models of disease, such as
Parkinson's and Alzheimer's, suggesting that novel therapeutic strategies could
be based on the modulation of TFEB activity. In this Cell Science at a Glance
article and accompanying poster, we present an overview of the latest research on
TFEB function and its implication in human diseases.
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