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2015 ; 6
(ä): 292
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TCR-Signaling Events in Cellular Metabolism and Specialization
#MMPMID26106392
Chisolm DA
; Weinmann AS
Front Immunol
2015[]; 6
(ä): 292
PMID26106392
show ga
Engaging the T cell receptor (TCR) with peptide:MHC complexes initiates a cascade
of signaling events that activates T cells in an antigen-specific manner. It is
now clear that multiple inputs, including the strength of TCR signaling,
co-stimulation, and the cytokine environment, impact T cell specialization
decisions in the context of specific pathogenic encounters. Additionally, it is
now appreciated that these same stimuli direct cellular metabolism programs. In
this review, we will discuss how TCR-signaling events coordinate cellular
metabolism and specialization gene programs in T cells.