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10.1038/cddis.2017.23 http://scihub22266oqcxt.onion/10.1038/cddis.2017.23 C5386472!5386472 !28182011     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28182011 &cmd=llinks): Failed to open stream: HTTP request failed! 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TAK1 regulates resident macrophages by protecting lysosomal integrity |pdf=|usr=}}{{28182011 }} gab.com Text TAK1 regulates resident macrophages by protecting lysosomal integrity JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=28182011 #FOAvip Hematopoietic cell survival and death is critical for development of a functional immune system. Here, we report that a protein kinase, TAK1, is selectively required for resident macrophage integrity during embryogenesis. Hematopoietic lineage-specific deletion of Tak1 gene (Tak1(HKO)) caused accumulation of cellular debris in the thymus in perinatal mice. Although no overt alteration in thymocytes and blood myeloid populations was observed in Tak1(HKO) mice, we found that thymic and lung macrophages were diminished. In the in vitro setting, Tak1 deficiency caused profound disruption of lysosomes and killed bone marrow-derived macrophages (BMDMs) without any exogenous stressors. Inhibition of the lysosomal protease, cathepsin B, partially blocked Tak1-deficient BMDM death, suggesting that leakage of the lysosomal contents is in part the cause of cell death. To identify the trigger of this cell death, we examined involvement of TNF and Toll-like receptor pathways. Among them, we found that deletion of Tnfr1 partially rescued cell death. Finally, we show that Tnfr1 deletion partially restored thymic and lung macrophages in vivo. These results suggest that autocrine and potentially paracrine TNF kills Tak1-deficient macrophages during development. Our results reveal that TAK1 signaling maintains proper macrophage populations through protecting lysosomal integrity. Twit Text FOAVip TAK1 regulates resident macrophages by protecting lysosomal integrity ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=28182011 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28182011 #FOAvip English Wikipedia <ref>{{Cite pmid|28182011 }}</ref> TAK1 regulates resident macrophages by protecting lysosomal integrity #MMPMID28182011 Sakamachi Y ; Morioka S ; Mihaly SR ; Takaesu G ; Foley JF ; Fessler MB ; Ninomiya-Tsuji J Cell Death Dis 2017[Feb]; 8 (2 ): e2598 PMID28182011 show ga Hematopoietic cell survival and death is critical for development of a functional immune system. Here, we report that a protein kinase, TAK1, is selectively required for resident macrophage integrity during embryogenesis. Hematopoietic lineage-specific deletion of Tak1 gene (Tak1(HKO)) caused accumulation of cellular debris in the thymus in perinatal mice. Although no overt alteration in thymocytes and blood myeloid populations was observed in Tak1(HKO) mice, we found that thymic and lung macrophages were diminished. In the in vitro setting, Tak1 deficiency caused profound disruption of lysosomes and killed bone marrow-derived macrophages (BMDMs) without any exogenous stressors. Inhibition of the lysosomal protease, cathepsin B, partially blocked Tak1-deficient BMDM death, suggesting that leakage of the lysosomal contents is in part the cause of cell death. To identify the trigger of this cell death, we examined involvement of TNF and Toll-like receptor pathways. Among them, we found that deletion of Tnfr1 partially rescued cell death. Finally, we show that Tnfr1 deletion partially restored thymic and lung macrophages in vivo. These results suggest that autocrine and potentially paracrine TNF kills Tak1-deficient macrophages during development. Our results reveal that TAK1 signaling maintains proper macrophage populations through protecting lysosomal integrity. |Animals [MESH] |Cell Death/physiology [MESH] |Cell Survival/physiology [MESH] |Embryonic Development/physiology [MESH] |Lung/metabolism [MESH] |Lysosomes/*metabolism [MESH] |MAP Kinase Kinase Kinases/*metabolism [MESH] |Macrophages/*metabolism [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Protective Agents/*metabolism [MESH] |Receptors, Tumor Necrosis Factor, Type I/metabolism [MESH] |Signal Transduction/physiology [MESH] |Thymocytes/physiology [MESH] |Thymus Gland/metabolism [MESH]TAK1 regulates resident macrophages by protecting lysosomal integrity (epmc).pdf DeepDyve Pubget Overpricing