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2015 ; 6
(6
): e1792
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T-cell exhaustion in the tumor microenvironment
#MMPMID26086965
Jiang Y
; Li Y
; Zhu B
Cell Death Dis
2015[Jun]; 6
(6
): e1792
PMID26086965
show ga
T-cell exhaustion was originally identified during chronic infection in mice, and
was subsequently observed in humans with cancer. The exhausted T cells in the
tumor microenvironment show overexpressed inhibitory receptors, decreased
effector cytokine production and cytolytic activity, leading to the failure of
cancer elimination. Restoring exhausted T cells represents an inspiring strategy
for cancer treatment, which has yielded promising results and become a
significant breakthrough in the cancer immunotherapy. In this review, we overview
the updated understanding on the exhausted T cells in cancer and their potential
regulatory mechanisms and discuss current therapeutic interventions targeting
exhausted T cells in clinical trials.
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