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10.1016/j.virol.2014.12.033 http://scihub22266oqcxt.onion/10.1016/j.virol.2014.12.033 C4424083!4424083 !25620767     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25620767 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25620767 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Virology 2015 ; 479-480 (ä): 180-93 Nephropedia Template TP {{tp|p=25620767 |t=2015. T cell exhaustion during persistent viral infections |pdf=|usr=}}{{25620767 }} gab.com Text T cell exhaustion during persistent viral infections JO: Virology http://www.kidney.de/pget.php?&tw=1&pmid=25620767 #FOAvip Although robust and highly effective anti-viral T cells contribute to the clearance of many acute infections, viral persistence is associated with the development of functionally inferior, exhausted, T cell responses. Exhaustion develops in a step-wise and progressive manner, ranges in severity, and can culminate in the deletion of the anti-viral T cells. This disarming of the response is consequential as it compromises viral control and potentially serves to dampen immune-mediated damage. Exhausted T cells are unable to elaborate typical anti-viral effector functions. They are characterized by the sustained upregulation of inhibitory receptors and display a gene expression profile that distinguishes them from prototypic effector and memory T cell populations. In this review we discuss the properties of exhausted T cells; the virological and immunological conditions that favor their development; the cellular and molecular signals that sustain the exhausted state; and strategies for preventing and reversing exhaustion to favor viral control. Twit Text FOAVip T cell exhaustion during persistent viral infections ????Virology http://www.kidney.de/pget.php?&tw=1&pmid=25620767 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25620767 #FOAvip English Wikipedia <ref>{{Cite pmid|25620767 }}</ref> T cell exhaustion during persistent viral infections #MMPMID25620767 Kahan SM ; Wherry EJ ; Zajac AJ Virology 2015[May]; 479-480 (ä): 180-93 PMID25620767 show ga Although robust and highly effective anti-viral T cells contribute to the clearance of many acute infections, viral persistence is associated with the development of functionally inferior, exhausted, T cell responses. Exhaustion develops in a step-wise and progressive manner, ranges in severity, and can culminate in the deletion of the anti-viral T cells. This disarming of the response is consequential as it compromises viral control and potentially serves to dampen immune-mediated damage. Exhausted T cells are unable to elaborate typical anti-viral effector functions. They are characterized by the sustained upregulation of inhibitory receptors and display a gene expression profile that distinguishes them from prototypic effector and memory T cell populations. In this review we discuss the properties of exhausted T cells; the virological and immunological conditions that favor their development; the cellular and molecular signals that sustain the exhausted state; and strategies for preventing and reversing exhaustion to favor viral control. |Animals [MESH] |Chronic Disease [MESH] |Gene Expression [MESH] |Host-Pathogen Interactions [MESH] |Humans [MESH] |T-Lymphocytes/*immunology [MESH]T cell exhaustion during persistent viral infections (epmc).pdf DeepDyve Pubget Overpricing