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2015 ; 4
(4
): 640-63
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T Cells in Fish
#MMPMID26426066
Nakanishi T
; Shibasaki Y
; Matsuura Y
Biology (Basel)
2015[Sep]; 4
(4
): 640-63
PMID26426066
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Cartilaginous and bony fish are the most primitive vertebrates with a thymus, and
possess T cells equivalent to those in mammals. There are a number of studies in
fish demonstrating that the thymus is the essential organ for development of T
lymphocytes from early thymocyte progenitors to functionally competent T cells. A
high number of T cells in the intestine and gills has been reported in several
fish species. Involvement of CD4? and CD8?? T cells in allograft rejection and
graft-versus-host reaction (GVHR) has been demonstrated using monoclonal
antibodies. Conservation of CD4? helper T cell functions among teleost fishes has
been suggested in a number studies employing mixed leukocyte culture (MLC) and
hapten/carrier effect. Alloantigen- and virus-specific cytotoxicity has also been
demonstrated in ginbuna and rainbow trout. Furthermore, the important role of
cell-mediated immunity rather than humoral immunity has been reported in the
protection against intracellular bacterial infection. Recently, the direct
antibacterial activity of CD8??, CD4? T-cells and sIgM? cells in fish has been
reported. In this review, we summarize the recent progress in T cell research
focusing on the tissue distribution and function of fish T cells.
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