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2016 ; 44
(5
): 1020-33
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English Wikipedia
T Cell Cosignaling Molecules in Transplantation
#MMPMID27192567
Ford ML
Immunity
2016[May]; 44
(5
): 1020-33
PMID27192567
show ga
The ultimate outcome of alloreactivity versus tolerance following transplantation
is potently influenced by the constellation of cosignaling molecules expressed by
immune cells during priming with alloantigen, and the net sum of costimulatory
and coinhibitory signals transmitted via ligation of these molecules. Intense
investigation over the last two decades has yielded a detailed understanding of
the kinetics, cellular distribution, and intracellular signaling networks of
cosignaling molecules such as the CD28, TNF, and TIM families of receptors in
alloimmunity. More recent work has better defined the cellular and molecular
mechanisms by which engagement of cosignaling networks serve to either dampen or
augment alloimmunity. These findings will likely aid in the rational development
of novel immunomodulatory strategies to prolong graft survival and improve
outcomes following transplantation.
|*Organ Transplantation
[MESH]
|*Receptor Cross-Talk
[MESH]
|Animals
[MESH]
|CD28 Antigens/metabolism
[MESH]
|Cell Cycle Proteins/metabolism
[MESH]
|Graft Rejection/*immunology/prevention & control
[MESH]
|Humans
[MESH]
|Immunotherapy/*methods/trends
[MESH]
|Intracellular Signaling Peptides and Proteins/metabolism
[MESH]
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