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2017 ; 9
(4
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Systems biology of oxygen homeostasis
#MMPMID28221004
Samanta D
; Prabhakar NR
; Semenza GL
Wiley Interdiscip Rev Syst Biol Med
2017[Jul]; 9
(4
): ä PMID28221004
show ga
Metazoan species maintain oxygen homeostasis through the activity of
hypoxia-inducible factors, which are transcriptional activators that regulate the
expression of hundreds of genes to match O(2) supply and demand. Here, we review
the involvement of hypoxia-inducible factors in the molecular physiology and
pathophysiology of cellular O(2) sensing, O(2) delivery, O(2) utilization, and
systemic O(2) sensing. WIREs Syst Biol Med 2017, 9:e1382. doi: 10.1002/wsbm.1382
For further resources related to this article, please visit the WIREs website.