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10.1172/JCI81505

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suck abstract from ncbi


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pmid25893597
      J+Clin+Invest 2015 ; 125 (5 ): 1793-5
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  • Systems biology of diuretic resistance #MMPMID25893597
  • Knepper MA
  • J Clin Invest 2015[May]; 125 (5 ): 1793-5 PMID25893597 show ga
  • Diuretics are commonly used to treat hypertension and extracellular fluid volume expansion. However, the development of compensatory responses in the kidney limits the benefit of this class of drugs. In this issue of the JCI, Grimm and colleagues use a systems biology approach in mice lacking the kinase SPAK and unravel a complex mechanism that explains thiazide diuretic resistance. The overall process involves interactions among six different cell types in the kidney.
  • |Animals [MESH]
  • |Blood Pressure/*physiology [MESH]
  • |Chlorides/*urine [MESH]
  • |Gitelman Syndrome/*physiopathology [MESH]
  • |Male [MESH]
  • |Natriuresis/*physiology [MESH]
  • |Nephrons/*metabolism [MESH]


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