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2014 ; 60
(2
): 736-43
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Systems biology for hepatologists
#MMPMID24449428
Mato JM
; Martínez-Chantar ML
; Lu SC
Hepatology
2014[Aug]; 60
(2
): 736-43
PMID24449428
show ga
Medicine is expected to benefit from combining usual cellular and molecular
studies with high-throughput methods (genomics, transcriptomics, proteomics, and
metabolomics). These methods, collectively known as omics, permit the
determination of thousands of molecules (variations within genes, RNAs, proteins,
metabolites) within a tissue, cell, or biological fluid. The use of these methods
is very demanding in terms of the design of the study, acquisition, storage,
analysis, and interpretation of the data. When carried out properly, these
studies can reveal new etiological pathways, help to identify patients at risk
for disease, and predict the response to specific treatments. Here we review
these omics methods and mention several applications in hepatology research.