Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24842079
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24842079
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Curr+Opin+Virol
2014 ; 6
(ä): 61-9
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Systems approaches to Coronavirus pathogenesis
#MMPMID24842079
Schäfer A
; Baric RS
; Ferris MT
Curr Opin Virol
2014[Jun]; 6
(ä): 61-9
PMID24842079
show ga
Coronaviruses comprise a large group of emergent human and animal pathogens,
including the highly pathogenic SARS-CoV and MERS-CoV strains that cause
significant morbidity and mortality in infected individuals, especially the
elderly. As emergent viruses may cause episodic outbreaks of disease over time,
human samples are limited. Systems biology and genetic technologies maximize
opportunities for identifying critical host and viral genetic factors that
regulate susceptibility and virus-induced disease severity. These approaches
provide discovery platforms that highlight and allow targeted confirmation of
critical targets for prophylactics and therapeutics, especially critical in an
outbreak setting. Although poorly understood, it has long been recognized that
host regulation of virus-associated disease severity is multigenic. The advent of
systems genetic and biology resources provides new opportunities for
deconvoluting the complex genetic interactions and expression networks that
regulate pathogenic or protective host response patterns following virus
infection. Using SARS-CoV as a model, dynamic transcriptional network changes and
disease-associated phenotypes have been identified in different genetic
backgrounds, leading to the promise of population-wide discovery of the
underpinnings of Coronavirus pathogenesis.