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10.3390/ijms17020246 http://scihub22266oqcxt.onion/10.3390/ijms17020246 C4783977!4783977 !26901192     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26901192 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26901192 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2016 ; 17 (2 ): 246 Nephropedia Template TP {{tp|p=26901192 |t=2016. Systems Pharmacology in Small Molecular Drug Discovery |pdf=|usr=}}{{26901192 }} gab.com Text Systems Pharmacology in Small Molecular Drug Discovery JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26901192 #FOAvip Drug discovery is a risky, costly and time-consuming process depending on multidisciplinary methods to create safe and effective medicines. Although considerable progress has been made by high-throughput screening methods in drug design, the cost of developing contemporary approved drugs did not match that in the past decade. The major reason is the late-stage clinical failures in Phases II and III because of the complicated interactions between drug-specific, human body and environmental aspects affecting the safety and efficacy of a drug. There is a growing hope that systems-level consideration may provide a new perspective to overcome such current difficulties of drug discovery and development. The systems pharmacology method emerged as a holistic approach and has attracted more and more attention recently. The applications of systems pharmacology not only provide the pharmacodynamic evaluation and target identification of drug molecules, but also give a systems-level of understanding the interaction mechanism between drugs and complex disease. Therefore, the present review is an attempt to introduce how holistic systems pharmacology that integrated in silico ADME/T (i.e., absorption, distribution, metabolism, excretion and toxicity), target fishing and network pharmacology facilitates the discovery of small molecular drugs at the system level. Twit Text FOAVip Systems Pharmacology in Small Molecular Drug Discovery ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26901192 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26901192 #FOAvip English Wikipedia <ref>{{Cite pmid|26901192 }}</ref> Systems Pharmacology in Small Molecular Drug Discovery #MMPMID26901192 Zhou W ; Wang Y ; Lu A ; Zhang G Int J Mol Sci 2016[Feb]; 17 (2 ): 246 PMID26901192 show ga Drug discovery is a risky, costly and time-consuming process depending on multidisciplinary methods to create safe and effective medicines. Although considerable progress has been made by high-throughput screening methods in drug design, the cost of developing contemporary approved drugs did not match that in the past decade. The major reason is the late-stage clinical failures in Phases II and III because of the complicated interactions between drug-specific, human body and environmental aspects affecting the safety and efficacy of a drug. There is a growing hope that systems-level consideration may provide a new perspective to overcome such current difficulties of drug discovery and development. The systems pharmacology method emerged as a holistic approach and has attracted more and more attention recently. The applications of systems pharmacology not only provide the pharmacodynamic evaluation and target identification of drug molecules, but also give a systems-level of understanding the interaction mechanism between drugs and complex disease. Therefore, the present review is an attempt to introduce how holistic systems pharmacology that integrated in silico ADME/T (i.e., absorption, distribution, metabolism, excretion and toxicity), target fishing and network pharmacology facilitates the discovery of small molecular drugs at the system level. |*Drug Discovery/methods [MESH] |*Pharmacology/methods [MESH] |*Small Molecule Libraries [MESH] |*Systems Biology/methods [MESH] |Computational Biology/methods [MESH] |Computer Simulation [MESH] |Drug Design [MESH] |Humans [MESH] |Ligands [MESH] |Molecular Targeted Therapy [MESH] |Neural Networks, Computer [MESH] |Phenotype [MESH]Systems Pharmacology in Small Molecular Drug Discovery (epmc).pdf DeepDyve Pubget Overpricing