10.1002/cpns.23 http://scihub22266oqcxt.onion/10.1002/cpns.23 C5548442!5548442
!28398643
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Curr+Protoc+Neurosci
2017 ; 79
(?): 8.39.1-8.39.20
Nephropedia Template TP gab.com Text Twit Text FOAVip Twit Text # English Wikipedia
Systems Genetic Analysis in GeneNetwork org
#MMPMID28398643
Parker CC
; Dickson PE
; Philip VM
; Thomas M
; Chesler EJ
Curr Protoc Neurosci
2017[Apr]; 79
(?): 8.39.1-8.39.20
PMID28398643
show ga
Genome-wide association studies (GWAS) have emerged as a powerful tool to
identify alleles and molecular pathways that influence susceptibility to
psychiatric disorders and other diseases. Forward genetics using mouse mapping
populations allows for a complementary approach that provides rigorous genetic
and environmental control. In this unit, we describe techniques and tools that
reduce the technical burden traditionally associated with genetic mapping in mice
and enhance their translational utility to human psychiatric disorders. We
provide guidance on choosing the appropriate mapping population, discuss the
importance of phenotype, and offer detailed instructions on using the Web-based
resource GeneNetwork to aid neuroscientists in better understanding the
mechanisms through which genes influence behavior. We believe that the continued
development of mouse mapping populations, genetic tools, bioinformatics
resources, and statistical methodologies should remain a parallel strategy by
which to investigate the genetic and environmental underpinnings of psychiatric
disorders and other diseases in humans. © 2017 by John Wiley & Sons, Inc.
Please enable JavaScript to view the comments powered by Disqus. |Alleles
[MESH] |Animals
[MESH] |Chromosome Mapping/*methods
[MESH] |Databases, Genetic
[MESH] |Genome-Wide Association Study/*methods
[MESH] |Genotype
[MESH] |Humans
[MESH] DeepDyve Pubget Overpricing