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2016 ; 11
(ä): 29
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Systemic manifestations of hepatitis C infection
#MMPMID27222662
Tang L
; Marcell L
; Kottilil S
Infect Agent Cancer
2016[]; 11
(ä): 29
PMID27222662
show ga
Chronic hepatitis C (HCV) is a common infection affecting 185 million people
worldwide. The most common manifestation of chronic HCV is progressive liver
fibrosis, cirrhosis, liver failure and hepatocellular carcinoma. However, several
systemic manifestations of HCV have been recognized and reported in the
literature. The purpose of this review is to assimilate published literature
based on evidence to categorize these extrahepatic manifestations with the
likelihood of a causal association with HCV. Exciting recent developments have
resulted in simple all oral interferon-free highly effective therapy for HCV.
However, this treatment is also expensive and less accessible to most affected
individuals as treatment recommendations are based on stage of liver fibrosis.
Expanding the scope of HCV therapy to those with extrahepatic manifestations
beyond what is currently recommended will significantly reduce the morbidity and
mortality in this aging population.