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10.1074/jbc.R115.639799 http://scihub22266oqcxt.onion/10.1074/jbc.R115.639799 C4400370!4400370 !25750126     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25750126 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biol+Chem 2015 ; 290 (16 ): 9951-8 Nephropedia Template TP {{tp|p=25750126 |t=2015. Systemic amyloidosis: lessons from ?2-microglobulin |pdf=|usr=}}{{25750126 }} gab.com Text Systemic amyloidosis: lessons from 2-microglobulin JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25750126 #FOAvip ?2-Microglobulin is responsible for systemic amyloidosis affecting patients undergoing long-term hemodialysis. Its genetic variant D76N causes a very rare form of familial systemic amyloidosis. These two types of amyloidoses differ significantly in terms of the tissue localization of deposits and for major pathological features. Considering how the amyloidogenesis of the ?2-microglobulin mechanism has been scrutinized in depth for the last three decades, the comparative analysis of molecular and pathological properties of wild type ?2-microglobulin and of the D76N variant offers a unique opportunity to critically reconsider the current understanding of the relation between the protein's structural properties and its pathologic behavior. Twit Text FOAVip Systemic amyloidosis: lessons from 2-microglobulin ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25750126 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25750126 #FOAvip English Wikipedia <ref>{{Cite pmid|25750126 }}</ref> Systemic amyloidosis: lessons from ?2-microglobulin #MMPMID25750126 Stoppini M ; Bellotti V J Biol Chem 2015[Apr]; 290 (16 ): 9951-8 PMID25750126 show ga ?2-Microglobulin is responsible for systemic amyloidosis affecting patients undergoing long-term hemodialysis. Its genetic variant D76N causes a very rare form of familial systemic amyloidosis. These two types of amyloidoses differ significantly in terms of the tissue localization of deposits and for major pathological features. Considering how the amyloidogenesis of the ?2-microglobulin mechanism has been scrutinized in depth for the last three decades, the comparative analysis of molecular and pathological properties of wild type ?2-microglobulin and of the D76N variant offers a unique opportunity to critically reconsider the current understanding of the relation between the protein's structural properties and its pathologic behavior. |Amyloid/antagonists & inhibitors/*chemistry/metabolism [MESH] |Amyloidosis/classification/*drug therapy/etiology/genetics [MESH] |Doxycycline/pharmacology [MESH] |Humans [MESH] |Models, Molecular [MESH] |Mutation [MESH] |Protein Aggregation, Pathological/metabolism/*prevention & control [MESH] |Protein Conformation [MESH] |Renal Dialysis/adverse effects [MESH] |Single-Chain Antibodies/pharmacology [MESH]Systemic amyloidosis: lessons from ?2-microglobulin (epmc).pdf DeepDyve Pubget Overpricing