Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27134818
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Systemic Control of Bone Homeostasis by FGF23 Signaling
#MMPMID27134818
Clinkenbeard EL
; White KE
Curr Mol Biol Rep
2016[Mar]; 2
(1
): 62-71
PMID27134818
show ga
The regulation of phosphate metabolism as an influence on bone homeostasis is
profound. Recent advances in understanding the systemic control of Fibroblast
growth factor-23 (FGF23) has uncovered novel effectors of endocrine feedback
loops for calcium, phosphate, and vitamin D balance that interact with
'traditional' feedback loops for mineral metabolism. Not only are these findings
re-shaping research studying phosphate handling and skeletal interactions, they
have provided new therapeutic interventions. Emerging data support that the
control of FGF23 production in bone and its circulating concentrations is a
multi-layered process, with some influences affecting FGF23 transcription and
some post-translational modification of the secreted, bioactive protein.
Additionally, the actions of FGF23 on its target tissues via its co-receptor
?Klotho, are subject to regulatory events just coming to light. The recent
findings of systemic influences on circulating FGF23 and the downstream
manifestations on bone homeostasis will be reviewed herein.
free
free
free
