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2017 ; 176
(9
): 1155-1162
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Systematic review: probiotics for functional constipation in children
#MMPMID28762070
Wojtyniak K
; Szajewska H
Eur J Pediatr
2017[Sep]; 176
(9
): 1155-1162
PMID28762070
show ga
We updated our 2010 systematic review on the efficacy of probiotics in the
treatment of constipation in children. The MEDLINE, EMBASE, and Cochrane Library
databases; clinical trial registries; and reference lists of included studies
were searched to February 2017 for randomized controlled trials (RCTs) performed
in children, with no language restriction. The primary outcome measure was
treatment success, as defined by the investigators. We included seven RCTs with a
total of 515 participants. Included trials were heterogeneous with respect to
study population, probiotic strains, dosages, study duration, and follow-up.
Pooled results of two RCTs showed no significant difference between the
Lactobacillus rhamnosus casei Lcr35 and placebo groups with respect to treatment
success. Other probiotics were studied in single trials only. There was no
significant difference between the probiotic and control groups with respect to
treatment success. While some probiotic strains showed some effects on defecation
frequency, none of the probiotics had beneficial effects on frequency of fecal
incontinence or frequency of abdominal pain. Adverse events were rare and not
serious. CONCLUSION: Limited evidence does not support the use of any of
currently evaluated probiotics in the treatment of functional constipation in
children. What is Known: ? Conventional treatment for functional constipation in
children does not always provide satisfying improvement. ? Probiotics have been
suggested as potential treatment modalities for this condition. What is New: ?
Probiotics are ineffective for the management of functional constipation in
children in terms of treatment success, frequency of fecal incontinence, and
frequency of abdominal pain.