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2016 ; 37
(ä): 46-50
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Systematic approaches to identify functional lncRNAs
#MMPMID26821363
Alcid EA
; Tsukiyama T
Curr Opin Genet Dev
2016[Apr]; 37
(ä): 46-50
PMID26821363
show ga
Long noncoding RNAs (lncRNAs) were discovered in eukaryotes more than 30 years
ago [1]. Recent advances in genomics have led to the discovery that lncRNAs are
transcribed pervasively across the genome [2(?),3,4,5(?)]. There are an
increasing number of reports that identify lncRNAs whose expression is modulated
during cell differentiation or in disease states. However, biological functions
for the vast majority of them are yet to be determined. Here, we propose two ways
to identify lncRNAs that have biological functions: to identify lncRNAs with
dedicated preinitiation complexes (PICs), and to focus on those whose
transcription is highly regulated.
|Eukaryota/*genetics
[MESH]
|Gene Expression Regulation/genetics
[MESH]
|Genome/genetics
[MESH]
|RNA, Long Noncoding/*genetics/isolation & purification
[MESH]