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10.2147/DDDT.S58049 http://scihub22266oqcxt.onion/10.2147/DDDT.S58049 C4675648!4675648!26673570     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26673570.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Drug+Des+Devel+Ther 2015 ; 9 (ä): 6285-302 Nephropedia Template TP {{tp|p=26673570|t=2015. Synthetic biology for pharmaceutical drug discovery |pdf=|usr=}}{{26673570}} gab.com Text Synthetic biology for pharmaceutical drug discovery JO: Drug Des Devel Ther http://www.kidney.de/pget.php?&tw=1&pmid=26673570 #FOAvip Synthetic biology (SB) is an emerging discipline, which is slowly reorienting the field of drug discovery. For thousands of years, living organisms such as plants were the major source of human medicines. The difficulty in resynthesizing natural products, however, often turned pharmaceutical industries away from this rich source for human medicine. More recently, progress on transformation through genetic manipulation of biosynthetic units in microorganisms has opened the possibility of in-depth exploration of the large chemical space of natural products derivatives. Success of SB in drug synthesis culminated with the bioproduction of artemisinin by microorganisms, a tour de force in protein and metabolic engineering. Today, synthetic cells are not only used as biofactories but also used as cell-based screening platforms for both target-based and phenotypic-based approaches. Engineered genetic circuits in synthetic cells are also used to decipher disease mechanisms or drug mechanism of actions and to study cell?cell communication within bacteria consortia. This review presents latest developments of SB in the field of drug discovery, including some challenging issues such as drug resistance and drug toxicity. Twit Text FOAVip Synthetic biology for pharmaceutical drug discovery ????Drug Des Devel Ther http://www.kidney.de/pget.php?&tw=1&pmid=26673570 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26673570 #FOAvip English Wikipedia <ref>{{Cite pmid|26673570}}</ref> Synthetic biology for pharmaceutical drug discovery #MMPMID26673570 Trosset JY; Carbonell P Drug Des Devel Ther 2015[]; 9 (ä): 6285-302 PMID26673570show ga Synthetic biology (SB) is an emerging discipline, which is slowly reorienting the field of drug discovery. For thousands of years, living organisms such as plants were the major source of human medicines. The difficulty in resynthesizing natural products, however, often turned pharmaceutical industries away from this rich source for human medicine. More recently, progress on transformation through genetic manipulation of biosynthetic units in microorganisms has opened the possibility of in-depth exploration of the large chemical space of natural products derivatives. Success of SB in drug synthesis culminated with the bioproduction of artemisinin by microorganisms, a tour de force in protein and metabolic engineering. Today, synthetic cells are not only used as biofactories but also used as cell-based screening platforms for both target-based and phenotypic-based approaches. Engineered genetic circuits in synthetic cells are also used to decipher disease mechanisms or drug mechanism of actions and to study cell?cell communication within bacteria consortia. This review presents latest developments of SB in the field of drug discovery, including some challenging issues such as drug resistance and drug toxicity. äSynthetic biology for pharmaceutical drug discovery (epmc).pdf DeepDyve Pubget Overpricing