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10.1039/c4ob01053a http://scihub22266oqcxt.onion/10.1039/c4ob01053a C4146676!4146676 !24995943     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24995943 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Org+Biomol+Chem 2014 ; 12 (37 ): 7211-32 Nephropedia Template TP {{tp|p=24995943 |t=2014. Synthesis and immunological effects of heroin vaccines |pdf=|usr=}}{{24995943 }} gab.com Text Synthesis and immunological effects of heroin vaccines JO: Org Biomol Chem http://www.kidney.de/pget.php?&tw=1&pmid=24995943 #FOAvip Three haptens have been synthesized with linkers for attachment to carrier macromolecules at either the piperidino-nitrogen or via an introduced 3-amino group. Two of the haptens, with a 2-oxopropyl functionality at either C6, or at both the C3 and C6 positions on the 4,5-epoxymorphinan framework, as well as the third hapten (DiAmHap) with diamido moieties at both the C3 and C6 positions, should be much more stable in solution, or in vivo in a vaccine, than a hapten with an ester in one of those positions, as found in many heroin-based haptens. A "classical" opioid synthetic scheme enabled the formation of a 3-amino-4,5-epoxymorphinan which could not be obtained using palladium chemistry. Our vaccines are aimed at the reduction of the abuse of heroin and, as well, at the reduction of the effects of its predominant metabolites, 6-acetylmorphine and morphine. One of the haptens, DiAmHap, has given interesting results in a heroin vaccine and is clearly more suited for the purpose than the other two haptens. Twit Text FOAVip Synthesis and immunological effects of heroin vaccines ????Org Biomol Chem http://www.kidney.de/pget.php?&tw=1&pmid=24995943 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24995943 #FOAvip English Wikipedia <ref>{{Cite pmid|24995943 }}</ref> Synthesis and immunological effects of heroin vaccines #MMPMID24995943 Li F ; Cheng K ; Antoline JF ; Iyer MR ; Matyas GR ; Torres OB ; Jalah R ; Beck Z ; Alving CR ; Parrish DA ; Deschamps JR ; Jacobson AE ; Rice KC Org Biomol Chem 2014[Oct]; 12 (37 ): 7211-32 PMID24995943 show ga Three haptens have been synthesized with linkers for attachment to carrier macromolecules at either the piperidino-nitrogen or via an introduced 3-amino group. Two of the haptens, with a 2-oxopropyl functionality at either C6, or at both the C3 and C6 positions on the 4,5-epoxymorphinan framework, as well as the third hapten (DiAmHap) with diamido moieties at both the C3 and C6 positions, should be much more stable in solution, or in vivo in a vaccine, than a hapten with an ester in one of those positions, as found in many heroin-based haptens. A "classical" opioid synthetic scheme enabled the formation of a 3-amino-4,5-epoxymorphinan which could not be obtained using palladium chemistry. Our vaccines are aimed at the reduction of the abuse of heroin and, as well, at the reduction of the effects of its predominant metabolites, 6-acetylmorphine and morphine. One of the haptens, DiAmHap, has given interesting results in a heroin vaccine and is clearly more suited for the purpose than the other two haptens. |Animals [MESH] |Female [MESH] |Haptens/chemistry/*immunology [MESH] |Heroin Dependence/immunology/prevention & control/therapy [MESH] |Heroin/chemistry/*immunology [MESH] |Macromolecular Substances/chemical synthesis/chemistry/immunology [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Molecular Conformation [MESH]Synthesis and immunological effects of heroin vaccines (epmc).pdf DeepDyve Pubget Overpricing