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10.1021/ml300283f http://scihub22266oqcxt.onion/10.1021/ml300283f C4025792!4025792 !24900431     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24900431 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       ACS+Med+Chem+Lett 2012 ; 3 (12 ): 1075-80 Nephropedia Template TP {{tp|p=24900431 |t=2012. Synthesis and antiproliferative activities of ottelione a analogues |pdf=|usr=}}{{24900431 }} gab.com Text Synthesis and antiproliferative activities of ottelione a analogues JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900431 #FOAvip Through the syntheses of its C-1 desvinyl, C-7 methylene, C-7 exocyclic ethylidene, and various C-3 phenylmethyl analogues, the structure-activity relationship of antimitotic ottelione A (4) against tubulin and various cancer cells was established. The results indicated that compound 4 was a colchicine-competitive inhibitor and that the C-1 vinyl group is unnecessary for its potency, whereas the C-7 exocyclic double bond is essential, possibly because of its irreversible interaction with tubulin. Further optimization of the substituents on the phenylmethyl group at the C-3 position generated compound 10g with a 3'-fluoro-4'-methoxyphenylmethyl substituent, which was 6-38-fold more active against MCF-7, NCI-H460, and COLO205 cancer cells relative to 4. Results from in vitro tubulin polymerization assay confirmed the potency of compounds 4, 10g, and 11a. Twit Text FOAVip Synthesis and antiproliferative activities of ottelione a analogues ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=24900431 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24900431 #FOAvip English Wikipedia <ref>{{Cite pmid|24900431 }}</ref> Synthesis and antiproliferative activities of ottelione a analogues #MMPMID24900431 Chang TY ; Tu YP ; Wei WY ; Chen HY ; Chen CS ; Lee YS ; Huang JJ ; Sha CK ACS Med Chem Lett 2012[Dec]; 3 (12 ): 1075-80 PMID24900431 show ga Through the syntheses of its C-1 desvinyl, C-7 methylene, C-7 exocyclic ethylidene, and various C-3 phenylmethyl analogues, the structure-activity relationship of antimitotic ottelione A (4) against tubulin and various cancer cells was established. The results indicated that compound 4 was a colchicine-competitive inhibitor and that the C-1 vinyl group is unnecessary for its potency, whereas the C-7 exocyclic double bond is essential, possibly because of its irreversible interaction with tubulin. Further optimization of the substituents on the phenylmethyl group at the C-3 position generated compound 10g with a 3'-fluoro-4'-methoxyphenylmethyl substituent, which was 6-38-fold more active against MCF-7, NCI-H460, and COLO205 cancer cells relative to 4. Results from in vitro tubulin polymerization assay confirmed the potency of compounds 4, 10g, and 11a. äSynthesis and antiproliferative activities of ottelione a analogues (epmc).pdf DeepDyve Pubget Overpricing