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2018 ; 11
(ä): 23-32
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Synopsis of arachidonic acid metabolism: A review
#MMPMID30034873
Hanna VS
; Hafez EAA
J Adv Res
2018[May]; 11
(ä): 23-32
PMID30034873
show ga
Arachidonic acid (AA), a 20 carbon chain polyunsaturated fatty acid with 4 double
bonds, is an integral constituent of biological cell membrane, conferring it with
fluidity and flexibility. The four double bonds of AA predispose it to
oxygenation that leads to a plethora of metabolites of considerable importance
for the proper function of the immune system, promotion of allergies and
inflammation, resolving of inflammation, mood, and appetite. The present review
presents an illustrated synopsis of AA metabolism, corroborating the instrumental
importance of AA derivatives for health and well-being. It provides a
comprehensive outline on AA metabolic pathways, enzymes and signaling cascades,
in order to develop new perspectives in disease treatment and diagnosis.
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