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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Neurosci+Rural+Pract
2017 ; 8
(Suppl 1
): S66-S71
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Syndromes of Rapidly Progressive Cognitive Decline-Our Experience
#MMPMID28936074
Chandra SR
; Viswanathan LG
; Pai AR
; Wahatule R
; Alladi S
J Neurosci Rural Pract
2017[Aug]; 8
(Suppl 1
): S66-S71
PMID28936074
show ga
BACKGROUND: Dementias are fairly slowly progressive degenerative diseases of
brain for which treatment options are very less and carry a lot of burden on
family and society. A small percentage of them are rapidly progressive and mostly
carry a different course outcome. However, there are no definite criteria other
than the time line for these patients. AIMS: The aim of this was to identify and
categorize the causes and course of rapidly progressive dementias seen in our
center. SETTINGS AND DESIGN: Patients who presented with rapid deterioration of
cognitive functions within weeks to 1 year between 2011 and December 2016 were
evaluated. PATIENTS AND METHODS: All patients underwent all mandatory tests for
dementia including brain imaging. Complete vasculitis workup, autoimmune
encephalitis profile including Voltage Gated Potassium Channel,
N-methyl-D-aspartic acid receptor, glutamic acid-decarboxylase,
thyroid-peroxidase antibody, cerebrospinal fluid, and other special tests such as
duodenal biopsy and paraneoplastic workup were done based on clinical
indications. RESULTS AND CONCLUSIONS: Out of 144 patients 42 had immune-mediated
encephalopathy, 18 had Creutzfeldt-Jakob disease, 3 had Vitamin B12 deficiency,
63 had infection with neurocysticercosis, 7 had tuberculosis, 2 had HIV, 1 had
herpes simplex encephalitis, 1 had neurosyphilis, 1 Whipples disease, 1 had
Subacute Sclerosing Panencephalitis, 1 had Mass lesion, 3 had Frontotemporal
dementia, and 3 had small vessel disease. Good majority of these patients have
infective and immune-mediated causes and less number belong to degenerative
group. Therefore, caution is needed to look for treatable cause as it carries a
different treatment options and outcome.