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2016 ; 91
(5
): 683-685
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Syndrome in question: antisynthetase syndrome (anti-PL-7)
#MMPMID27828653
Esposito AC
; Gige TC
; Miot HA
An Bras Dermatol
2016[Sep]; 91
(5
): 683-685
PMID27828653
show ga
Antisynthetase syndrome is a rare autoimmune disease characterized by
interstitial lung disease and/or inflammatory myositis, with positive
antisynthetase antibodies (anti-Jo-1, anti-PL-7, anti-PL-12, ZO, OJ, anti-KE or
KS). Other symptoms described include: non-erosive arthritis, fever, Raynaud's
phenomenon, and "mechanic's hands." The first therapeutic option is
corticotherapy, followed by other immunosuppressants. The prognosis of the
disease is quite limited when compared to other inflammatory myopathies with
negative antisynthetase antibodies.