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10.1038/nature18015 http://scihub22266oqcxt.onion/10.1038/nature18015 C4964289!4964289 !27225121     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27225121 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27225121 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nature 2016 ; 533 (7604 ): 499-503 Nephropedia Template TP {{tp|p=27225121 |t=2016. Synchronized mitochondrial and cytosolic translation programs |pdf=|usr=}}{{27225121 }} gab.com Text Synchronized mitochondrial and cytosolic translation programs JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=27225121 #FOAvip Oxidative phosphorylation (OXPHOS) is a vital process for energy generation, and is carried out by complexes within the mitochondria. OXPHOS complexes pose a unique challenge for cells because their subunits are encoded on both the nuclear and the mitochondrial genomes. Genomic approaches designed to study nuclear/cytosolic and bacterial gene expression have not been broadly applied to mitochondria, so the co-regulation of OXPHOS genes remains largely unexplored. Here we monitor mitochondrial and nuclear gene expression in Saccharomyces cerevisiae during mitochondrial biogenesis, when OXPHOS complexes are synthesized. We show that nuclear- and mitochondrial-encoded OXPHOS transcript levels do not increase concordantly. Instead, mitochondrial and cytosolic translation are rapidly, dynamically and synchronously regulated. Furthermore, cytosolic translation processes control mitochondrial translation unidirectionally. Thus, the nuclear genome coordinates mitochondrial and cytosolic translation to orchestrate the timely synthesis of OXPHOS complexes, representing an unappreciated regulatory layer shaping the mitochondrial proteome. Our whole-cell genomic profiling approach establishes a foundation for studies of global gene regulation in mitochondria. Twit Text FOAVip Synchronized mitochondrial and cytosolic translation programs ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=27225121 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27225121 #FOAvip English Wikipedia <ref>{{Cite pmid|27225121 }}</ref> Synchronized mitochondrial and cytosolic translation programs #MMPMID27225121 Couvillion MT ; Soto IC ; Shipkovenska G ; Churchman LS Nature 2016[May]; 533 (7604 ): 499-503 PMID27225121 show ga Oxidative phosphorylation (OXPHOS) is a vital process for energy generation, and is carried out by complexes within the mitochondria. OXPHOS complexes pose a unique challenge for cells because their subunits are encoded on both the nuclear and the mitochondrial genomes. Genomic approaches designed to study nuclear/cytosolic and bacterial gene expression have not been broadly applied to mitochondria, so the co-regulation of OXPHOS genes remains largely unexplored. Here we monitor mitochondrial and nuclear gene expression in Saccharomyces cerevisiae during mitochondrial biogenesis, when OXPHOS complexes are synthesized. We show that nuclear- and mitochondrial-encoded OXPHOS transcript levels do not increase concordantly. Instead, mitochondrial and cytosolic translation are rapidly, dynamically and synchronously regulated. Furthermore, cytosolic translation processes control mitochondrial translation unidirectionally. Thus, the nuclear genome coordinates mitochondrial and cytosolic translation to orchestrate the timely synthesis of OXPHOS complexes, representing an unappreciated regulatory layer shaping the mitochondrial proteome. Our whole-cell genomic profiling approach establishes a foundation for studies of global gene regulation in mitochondria. |*Gene Expression Regulation, Fungal [MESH] |*Oxidative Phosphorylation [MESH] |*Protein Biosynthesis [MESH] |Cell Nucleus/*genetics/metabolism [MESH] |Cytosol/*metabolism [MESH] |Genes, Mitochondrial/genetics [MESH] |Mitochondria/genetics/metabolism [MESH] |Mitochondrial Proteins/*biosynthesis/genetics [MESH] |Organelle Biogenesis [MESH] |Proteome/biosynthesis/genetics [MESH] |RNA, Fungal/analysis/genetics/metabolism [MESH] |RNA, Messenger/analysis/genetics/metabolism [MESH]Synchronized mitochondrial and cytosolic translation programs (epmc).pdf DeepDyve Pubget Overpricing