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2013 ; 13
(ä): 31-86
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Synaptic effects induced by alcohol
#MMPMID21786203
Lovinger DM
; Roberto M
Curr Top Behav Neurosci
2013[]; 13
(ä): 31-86
PMID21786203
show ga
Ethanol (EtOH) has effects on numerous cellular molecular targets, and
alterations in synaptic function are prominent among these effects. Acute
exposure to EtOH activates or inhibits the function of proteins involved in
synaptic transmission, while chronic exposure often produces opposing and/or
compensatory/homeostatic effects on the expression, localization, and function of
these proteins. Interactions between different neurotransmitters (e.g.,
neuropeptide effects on release of small molecule transmitters) can also
influence both acute and chronic EtOH actions. Studies in intact animals indicate
that the proteins affected by EtOH also play roles in the neural actions of the
drug, including acute intoxication, tolerance, dependence, and the seeking and
drinking of EtOH. This chapter reviews the literature describing these acute and
chronic synaptic effects of EtOH and their relevance for synaptic transmission,
plasticity, and behavior.
|Animals
[MESH]
|Central Nervous System Depressants/*pharmacology
[MESH]
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