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2015 ; 226
(6
): 542-8
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Sympathetic innervation of human muscle spindles
#MMPMID25994126
Radovanovic D
; Peikert K
; Lindström M
; Domellöf FP
J Anat
2015[Jun]; 226
(6
): 542-8
PMID25994126
show ga
The aim of the present study was to investigate the presence of sympathetic
innervation in human muscle spindles, using antibodies against neuropeptide Y
(NPY), NPY receptors and tyrosine hydroxylase (TH). A total of 232 muscle
spindles were immunohistochemically examined. NPY and NPY receptors were found on
the intrafusal fibers, on the blood vessels supplying muscle spindles and on free
nerve endings in the periaxial space. TH-immunoreactivity was present mainly in
the spindle nerve and vessel. This is, to our knowledge, the first morphological
study concerning the sympathetic innervation of the human muscle spindles. The
results provide anatomical evidence for direct sympathetic innervation of the
intrafusal fibers and show that sympathetic innervation is not restricted to the
blood vessels supplying spindles. Knowledge about direct sympathetic innervation
of the muscle spindle might expand our understanding of motor and proprioceptive
dysfunction under stress conditions, for example, chronic muscle pain syndromes.
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