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2017 ; 249
(ä): 94-102
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Sustained epidermal powder drug delivery via skin microchannels
#MMPMID28132934
Cao Y
; Kakar P
; Hossen MN
; Wu MX
; Chen X
J Control Release
2017[Mar]; 249
(ä): 94-102
PMID28132934
show ga
Transdermal delivery of hydrophilic drugs is challenging. This study presents a
novel sustained epidermal powder delivery technology (sEPD) for safe, efficient,
and sustained delivery of hydrophilic drugs across the skin. sEPD is based on
coating powder drugs into high-aspect-ratio, micro-coating channels (MCCs)
followed by topical application of powder drug-coated array patches onto ablative
fractional laser-generated skin MCs to deliver drugs into the skin. We found sEPD
could efficiently deliver chemical drugs without excipients and biologics drugs
in the presence of sugar excipients into the skin with a duration of ~12h.
Interestingly the sEPD significantly improved zidovudine bioavailability by ~100%
as compared to oral gavage delivery. sEPD of insulin was found to maintain blood
glucose levels in normal range for at least 6h in chemical-induced diabetes mice,
while subcutaneous injection failed to maintain blood glucose levels in normal
range. sEPD of anti-programmed death-1 antibody showed more potent anti-tumor
efficacy than intraperitoneal injection in B16F10 melanoma models. Tiny skin MCs
and 'bulk' drug powder inside relatively deep MCCs are crucial to induce the
sustained drug release. The improved bioavailability and functionality warrants
further development of the novel sEPD for clinical use.
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