Survivin: a unique target for tumor therapy
#MMPMID27340370
Garg H
; Suri P
; Gupta JC
; Talwar GP
; Dubey S
Cancer Cell Int
2016[]; 16
(?): 49
PMID27340370
show ga
Survivin is the smallest member of the Inhibitor of apoptosis (IAP) family of
proteins, involved in inhibition of apoptosis and regulation of cell cycle. These
functional attributes make Survivin a unique protein exhibiting divergent
functions i.e. regulating cell proliferation and cell death. Expression pattern
of Survivin is also distinctive; it is prominently expressed during embryonal
development, absent in most normal, terminally differentiated tissues but
upregulated in a variety of human cancers. Expression of Survivin in tumours
correlates with not only inhibition of apoptosis and a decreased rate of cell
death, but also resistance to chemotherapy and aggressiveness of tumours.
Therefore, Survivin is an important target for cancer vaccines and therapeutics.
Survivin has also been found to be prominently expressed on both human and
embryonic stem cells and many somatic stem cell types indicating its yet
unexplored role in stem cell generation and maintenance. Overall, Survivin
emerges as a molecule with much wider role in cellular homeostasis. This review
will discuss various aspects of Survivin biology and its role in regulation of
apoptosis, cell division, chemo-resistance and tumour progression. Various
molecular and immunotherapeutic approaches targeting Survivin will also be
discussed.
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