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2015 ; 141
(4
): 389-97
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Survivin: A molecular biomarker in cancer
#MMPMID26112839
Jaiswal PK
; Goel A
; Mittal RD
Indian J Med Res
2015[Apr]; 141
(4
): 389-97
PMID26112839
show ga
Survivin, a member of the inhibitor of apoptosis (IAP) protein family that
inhibits caspases and blocks cell death, is highly expressed in most cancers and
is associated with a poor clinical outcome. Survivin has consistently been
identified by molecular profiling analysis to be associated with high tumour
grade cancers, different disease survival and recurrence. Polymorphisms in the
survivin gene are emerging as powerful tools to study the biology of the disease
and have the potential to be used in disease prognosis and diagnosis. The
survivin gene polymorphisms have also been reported to influence tumour
aggressiveness as well as survival of cancer patients. The differential
expression of survivin in cancer cells compared to normal tissues and its role as
a nodal protein in a number of cellular pathways make it a high target for
different therapeutics. This review discusses the complex circuitry of survivin
in human cancers and gene variants of survivin, and highlights novel therapy that
targets this important protein.
|*Molecular Targeted Therapy
[MESH]
|Apoptosis/genetics
[MESH]
|Biomarkers, Tumor/*genetics
[MESH]
|Gene Expression Regulation, Neoplastic
[MESH]
|Humans
[MESH]
|Inhibitor of Apoptosis Proteins/chemistry/*genetics
[MESH]
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