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2017 ; 50
(7
): 361-366
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Survivin protects fused cancer cells from cell death
#MMPMID28193315
Do M
; Kwak IH
; Ahn JH
; Lee IJ
; Lee JH
BMB Rep
2017[Jul]; 50
(7
): 361-366
PMID28193315
show ga
Tetraploidy, a potential precursor of cancer-associated aneuploidy, is produced
either by cell fusion or failure of cytokinesis. In this study, low
p53-expressing HeLa cells were used to address the fate of cancer cells after
fusion. We found that massive cell death or growth arrest occurred a few days
after fusion. Interestingly, cells with larger nuclei preferentially died after
fusion, suggesting that a larger deviation of DNA content is a strong inducer of
apoptosis. Notably, a fraction of cells escaped cell death. Also, the stability
of survivin increased, and its localization changed preferentially to the cytosol
in fused cells. Knockdown of survivin decreased the survival of fused cells, more
than observed in unfused cells, showing increased dependency of fused cells on
survivin. Collectively, after cancer cell fusion, some fused cells avoid the
apoptotic crisis partly owing to survivin, and continue to proliferate, a process
that contributes to human cancer progression. [BMB Reports 2017; 50(7): 361-366].
|Cell Death
[MESH]
|Cell Proliferation
[MESH]
|Female
[MESH]
|HeLa Cells
[MESH]
|Humans
[MESH]
|Inhibitor of Apoptosis Proteins/*metabolism
[MESH]
free
free
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